2021 Big 12 Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 8 | 148 | 1 | 0.80 |
| 2 | Kansas | 9 | 6 | 146 | 2 | 0.67 |
| 3 | Kansas State | 10 | 10 | 108 | 0 | 1.00 |
| 4 | West Virginia | 10 | 7 | 104 | 0 | 0.70 |
| 5 | Baylor | 9 | 7 | 87 | 1 | 0.78 |
| 5 | Texas Tech | 9 | 6 | 87 | 1 | 0.67 |
| 7 | TCU | 9 | 8 | 83 | 1 | 0.89 |
| 8 | Iowa State | 8 | 9 | 76 | 1 | 1.13 |
| 9 | Oklahoma | 10 | 7 | 60 | 0 | 0.70 |
| 10 | Texas | 7 | 2 | 42 | 1 | 0.29 |