2021 Big 12 Conference Leaders Interceptions - Games in December/January Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 2 | 7 | 160 | 1 | 3.50 |
| 2 | Kansas State | 1 | 2 | 32 | 0 | 2.00 |
| 3 | Oklahoma | 1 | 1 | 12 | 0 | 1.00 |
| 4 | Oklahoma State | 2 | 1 | 11 | 0 | 0.50 |
| 5 | Iowa State | 1 | 1 | 0 | 0 | 1.00 |
| 5 | Texas Tech | 1 | 1 | 0 | 0 | 1.00 |
| 5 | West Virginia | 1 | 1 | 0 | 0 | 1.00 |