2021 Big 12 Conference Leaders Opponent Penalties - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma | 11 | 72 | 592 | 6.5 | 53.8 |
| 2 | Oklahoma State | 10 | 71 | 544 | 7.1 | 54.4 |
| 3 | Baylor | 11 | 63 | 544 | 5.7 | 49.5 |
| 4 | Kansas State | 11 | 59 | 494 | 5.4 | 44.9 |
| 5 | Texas Tech | 10 | 58 | 499 | 5.8 | 49.9 |
| 6 | Iowa State | 11 | 57 | 547 | 5.2 | 49.7 |
| 7 | Kansas | 10 | 54 | 479 | 5.4 | 47.9 |
| 7 | West Virginia | 12 | 54 | 445 | 4.5 | 37.1 |
| 9 | TCU | 10 | 43 | 402 | 4.3 | 40.2 |
| 10 | Texas | 10 | 42 | 377 | 4.2 | 37.7 |