2021 Big 12 Conference Leaders Total Defense - Games in December/January Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kansas State | 1 | 170 | 138 | 48 | 308 | 6.42 | 308.0 |
| 2 | Iowa State | 1 | 128 | 187 | 73 | 315 | 4.32 | 315.0 |
| 3 | Texas Tech | 1 | 54 | 290 | 73 | 344 | 4.71 | 344.0 |
| 4 | West Virginia | 1 | 249 | 109 | 64 | 358 | 5.59 | 358.0 |
| 5 | Oklahoma | 1 | 191 | 306 | 73 | 497 | 6.81 | 497.0 |
| 6 | Baylor | 2 | 204 | 447 | 175 | 651 | 3.72 | 325.5 |
| 7 | Oklahoma State | 2 | 104 | 689 | 150 | 793 | 5.29 | 396.5 |