2021 Iowa State Cyclones Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 1590 | 2441 | 798 | 4031 | 5.05 | 310.1 |
| at Home | 6 | 630 | 1007 | 371 | 1637 | 4.41 | 272.8 |
| on Road/Neutral Site | 7 | 960 | 1434 | 427 | 2394 | 5.61 | 342.0 |
| in Wins | 7 | 739 | 1201 | 417 | 1940 | 4.65 | 277.1 |
| in Losses | 6 | 851 | 1240 | 381 | 2091 | 5.49 | 348.5 |
| vs. Conference | 9 | 1310 | 1824 | 555 | 3134 | 5.65 | 348.2 |
| vs. Non-Conference | 4 | 280 | 617 | 243 | 897 | 3.69 | 224.3 |
| vs. Ranked (AP) | 5 | 629 | 773 | 294 | 1402 | 4.77 | 280.4 |
| vs. Unranked (AP) | 8 | 961 | 1668 | 504 | 2629 | 5.22 | 328.6 |
| vs. FBS (I-A) | 12 | 1545 | 2211 | 738 | 3756 | 5.09 | 313.0 |
| vs. FCS (I-AA) | 1 | 45 | 230 | 60 | 275 | 4.58 | 275.0 |
| vs. FBS Winning | 7 | 972 | 1301 | 417 | 2273 | 5.45 | 324.7 |
| vs. FBS Non-Winning | 5 | 573 | 910 | 321 | 1483 | 4.62 | 296.6 |
| vs. FBS Power 5 | 11 | 1505 | 2117 | 688 | 3622 | 5.26 | 329.3 |
| vs. FBS non-Power 5 | 1 | 40 | 94 | 50 | 134 | 2.68 | 134.0 |
| in August/September | 4 | 275 | 589 | 222 | 864 | 3.89 | 216.0 |
| in October | 4 | 540 | 928 | 254 | 1468 | 5.78 | 367.0 |
| in November | 4 | 647 | 737 | 249 | 1384 | 5.56 | 346.0 |
| in December/January | 1 | 128 | 187 | 73 | 315 | 4.32 | 315.0 |