2021 Big 12 Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 40 | 94 | 50 | 134 | 2.68 | 134.0 |
| 2 | Kansas State | 1 | 25 | 306 | 64 | 331 | 5.17 | 331.0 |
| 3 | Oklahoma | 1 | 100 | 296 | 77 | 396 | 5.14 | 396.0 |
| 4 | Kansas | 1 | 215 | 245 | 61 | 460 | 7.54 | 460.0 |
| 5 | Texas Tech | 2 | 132 | 365 | 131 | 497 | 3.79 | 248.5 |
| 6 | TCU | 1 | 350 | 245 | 80 | 595 | 7.44 | 595.0 |
| 7 | Texas | 2 | 220 | 410 | 125 | 630 | 5.04 | 315.0 |
| 8 | Baylor | 2 | 146 | 498 | 122 | 644 | 5.28 | 322.0 |
| 9 | Oklahoma State | 3 | 226 | 975 | 225 | 1201 | 5.34 | 400.3 |