2021 Big 12 Conference Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 411 | 703 | 234 | 1114 | 4.76 | 278.5 |
| 2 | Iowa State | 4 | 540 | 928 | 254 | 1468 | 5.78 | 367.0 |
| 2 | Kansas State | 4 | 667 | 801 | 245 | 1468 | 5.99 | 367.0 |
| 4 | Baylor | 4 | 478 | 1076 | 279 | 1554 | 5.57 | 388.5 |
| 5 | West Virginia | 4 | 639 | 1049 | 249 | 1688 | 6.78 | 422.0 |
| 6 | Texas | 4 | 959 | 879 | 306 | 1838 | 6.01 | 459.5 |
| 7 | Kansas | 4 | 1039 | 889 | 260 | 1928 | 7.42 | 482.0 |
| 8 | Texas Tech | 5 | 776 | 1337 | 294 | 2113 | 7.19 | 422.6 |
| 9 | Oklahoma | 5 | 681 | 1569 | 327 | 2250 | 6.88 | 450.0 |
| 10 | TCU | 5 | 1091 | 1281 | 336 | 2372 | 7.06 | 474.4 |