2021 Conference USA Leaders Sacks - Games in December/January Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 5.0 | 33 | 2.50 |
| 2 | North Texas | 1 | 4.0 | 26 | 4.00 |
| 2 | UTSA | 2 | 4.0 | 24 | 2.00 |
| 4 | Marshall | 1 | 2.0 | 12 | 2.00 |
| 5 | Old Dominion | 1 | 1.0 | 7 | 1.00 |
| 5 | UAB | 1 | 1.0 | 5 | 1.00 |
| 5 | Middle Tennessee | 1 | 1.0 | 4 | 1.00 |
| 5 | UTEP | 1 | 1.0 | 1 | 1.00 |