2021 Conference USA Leaders Sacks - Games Won Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 12 | 32.0 | 248 | 2.67 |
| 2 | Western Kentucky | 9 | 31.0 | 190 | 3.44 |
| 3 | Marshall | 7 | 26.0 | 130 | 3.71 |
| 4 | Middle Tennessee | 7 | 24.0 | 182 | 3.43 |
| 5 | UAB | 9 | 21.0 | 153 | 2.33 |
| 5 | North Texas | 6 | 21.0 | 150 | 3.50 |
| 7 | UTEP | 7 | 19.0 | 137 | 2.71 |
| 8 | Old Dominion | 6 | 15.0 | 98 | 2.50 |
| 9 | Rice | 4 | 14.0 | 98 | 3.50 |
| 10 | Charlotte | 5 | 12.0 | 84 | 2.40 |
| 11 | Florida Atlantic | 5 | 10.0 | 69 | 2.00 |
| 12 | Southern Mississippi | 3 | 8.0 | 76 | 2.67 |
| 13 | Louisiana Tech | 3 | 7.0 | 39 | 2.33 |
| 14 | Florida International | 1 | 1.0 | 4 | 1.00 |