2021 Conference USA Leaders Sacks - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | North Texas | 13 | 38.0 | 263 | 2.92 |
| 1 | Marshall | 12 | 38.0 | 230 | 3.17 |
| 3 | Western Kentucky | 13 | 36.0 | 225 | 2.77 |
| 4 | UTSA | 13 | 32.0 | 248 | 2.46 |
| 4 | Middle Tennessee | 13 | 32.0 | 237 | 2.46 |
| 6 | UAB | 11 | 31.0 | 205 | 2.82 |
| 7 | UTEP | 13 | 25.0 | 174 | 1.92 |
| 8 | Old Dominion | 12 | 23.0 | 158 | 1.92 |
| 9 | Rice | 10 | 22.0 | 161 | 2.20 |
| 10 | Southern Mississippi | 11 | 21.0 | 155 | 1.91 |
| 11 | Louisiana Tech | 11 | 19.0 | 136 | 1.73 |
| 12 | Florida Atlantic | 12 | 17.0 | 136 | 1.42 |
| 12 | Charlotte | 12 | 17.0 | 119 | 1.42 |
| 14 | Florida International | 12 | 14.0 | 70 | 1.17 |