2021 Conference USA Leaders Sacks - Games Lost Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | North Texas | 7 | 17.0 | 113 | 2.43 |
| 2 | Southern Mississippi | 9 | 15.0 | 90 | 1.67 |
| 3 | Marshall | 6 | 14.0 | 112 | 2.33 |
| 4 | Louisiana Tech | 9 | 13.0 | 104 | 1.44 |
| 4 | Rice | 8 | 13.0 | 102 | 1.63 |
| 4 | Florida International | 11 | 13.0 | 66 | 1.18 |
| 7 | UAB | 4 | 11.0 | 57 | 2.75 |
| 8 | Old Dominion | 7 | 10.0 | 71 | 1.43 |
| 9 | Middle Tennessee | 6 | 8.0 | 55 | 1.33 |
| 10 | Florida Atlantic | 7 | 7.0 | 67 | 1.00 |
| 11 | UTEP | 6 | 6.0 | 37 | 1.00 |
| 12 | Western Kentucky | 5 | 5.0 | 35 | 1.00 |
| 12 | Charlotte | 7 | 5.0 | 35 | 0.71 |
| 14 | UTSA | 2 | 1.0 | 6 | 0.50 |