2021 Conference USA Leaders Rushing Defense - Games Won Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida International | 1 | 36 | 96 | 2.67 | 0 | 36.00 | 96.00 |
| 2 | Southern Mississippi | 3 | 97 | 372 | 3.84 | 1 | 32.33 | 124.00 |
| 3 | Louisiana Tech | 3 | 104 | 444 | 4.27 | 6 | 34.67 | 148.00 |
| 4 | Rice | 4 | 123 | 402 | 3.27 | 6 | 30.75 | 100.50 |
| 5 | Florida Atlantic | 5 | 145 | 419 | 2.89 | 3 | 29.00 | 83.80 |
| 6 | Charlotte | 5 | 179 | 927 | 5.18 | 7 | 35.80 | 185.40 |
| 7 | Old Dominion | 6 | 201 | 694 | 3.45 | 4 | 33.50 | 115.67 |
| 8 | North Texas | 6 | 216 | 791 | 3.66 | 4 | 36.00 | 131.83 |
| 9 | UTEP | 7 | 222 | 687 | 3.09 | 6 | 31.71 | 98.14 |
| 10 | Middle Tennessee | 7 | 235 | 764 | 3.25 | 6 | 33.57 | 109.14 |
| 11 | UAB | 9 | 289 | 879 | 3.04 | 10 | 32.11 | 97.67 |
| 12 | Marshall | 7 | 309 | 1373 | 4.44 | 4 | 44.14 | 196.14 |
| 13 | Western Kentucky | 9 | 324 | 1197 | 3.69 | 12 | 36.00 | 133.00 |
| 14 | UTSA | 12 | 389 | 1110 | 2.85 | 7 | 32.42 | 92.50 |