2021 Conference USA Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 9 | 286 | 1178 | 4.12 | 17 | 31.78 | 130.89 |
| 2 | Charlotte | 9 | 324 | 1593 | 4.92 | 21 | 36.00 | 177.00 |
| 3 | Florida Atlantic | 10 | 358 | 1457 | 4.07 | 13 | 35.80 | 145.70 |
| 4 | Louisiana Tech | 9 | 365 | 1663 | 4.56 | 18 | 40.56 | 184.78 |
| 5 | Southern Mississippi | 10 | 371 | 1595 | 4.30 | 14 | 37.10 | 159.50 |
| 6 | Middle Tennessee | 11 | 373 | 1456 | 3.90 | 12 | 33.91 | 132.36 |
| 7 | UAB | 11 | 395 | 1216 | 3.08 | 15 | 35.91 | 110.55 |
| 8 | North Texas | 11 | 405 | 1456 | 3.60 | 14 | 36.82 | 132.36 |
| 9 | Old Dominion | 11 | 410 | 1476 | 3.60 | 10 | 37.27 | 134.18 |
| 10 | UTSA | 12 | 418 | 1367 | 3.27 | 15 | 34.83 | 113.92 |
| 11 | Florida International | 10 | 433 | 2485 | 5.74 | 28 | 43.30 | 248.50 |
| 12 | UTEP | 12 | 438 | 1687 | 3.85 | 20 | 36.50 | 140.58 |
| 13 | Western Kentucky | 11 | 448 | 1831 | 4.09 | 19 | 40.73 | 166.45 |
| 14 | Marshall | 12 | 556 | 2425 | 4.36 | 18 | 46.33 | 202.08 |