2018 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 4 | 292 | 952 | 214 | 1244 | 5.81 | 311.0 |
| 2 | Southern Mississippi | 3 | 356 | 538 | 186 | 894 | 4.81 | 298.0 |
| 3 | UTSA | 4 | 547 | 1147 | 248 | 1694 | 6.83 | 423.5 |
| 4 | Marshall | 5 | 585 | 1362 | 343 | 1947 | 5.68 | 389.4 |
| 5 | North Texas | 5 | 593 | 1195 | 345 | 1788 | 5.18 | 357.6 |
| 6 | Western Kentucky | 4 | 700 | 812 | 273 | 1512 | 5.54 | 378.0 |
| 7 | Old Dominion | 4 | 807 | 1164 | 309 | 1971 | 6.38 | 492.8 |
| 8 | Louisiana Tech | 5 | 852 | 909 | 338 | 1761 | 5.21 | 352.2 |
| 9 | Florida Atlantic | 4 | 883 | 1017 | 271 | 1900 | 7.01 | 475.0 |
| 10 | Rice | 5 | 910 | 1498 | 310 | 2408 | 7.77 | 481.6 |
| 11 | Florida International | 5 | 956 | 1090 | 356 | 2046 | 5.75 | 409.2 |
| 12 | Middle Tennessee | 5 | 975 | 1087 | 319 | 2062 | 6.46 | 412.4 |
| 13 | UAB | 5 | 986 | 741 | 309 | 1727 | 5.59 | 345.4 |
| 14 | UTEP | 4 | 1021 | 653 | 253 | 1674 | 6.62 | 418.5 |