2016 American Athletic Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 1 | 79 | 96 | 55 | 175 | 3.18 | 175.0 |
| 2 | Houston | 2 | 171 | 534 | 143 | 705 | 4.93 | 352.5 |
| 3 | Temple | 2 | 241 | 530 | 133 | 771 | 5.80 | 385.5 |
| 4 | Connecticut | 3 | 356 | 831 | 210 | 1187 | 5.65 | 395.7 |
| 5 | UCF | 2 | 365 | 455 | 155 | 820 | 5.29 | 410.0 |
| 6 | Tulsa | 1 | 268 | 149 | 70 | 417 | 5.96 | 417.0 |
| 7 | East Carolina | 3 | 499 | 777 | 184 | 1276 | 6.93 | 425.3 |
| 8 | Memphis | 2 | 384 | 554 | 160 | 938 | 5.86 | 469.0 |
| 9 | Cincinnati | 1 | 103 | 401 | 82 | 504 | 6.15 | 504.0 |
| 10 | South Florida | 3 | 768 | 909 | 264 | 1677 | 6.35 | 559.0 |
| 11 | SMU | 2 | 412 | 713 | 181 | 1125 | 6.22 | 562.5 |