2020 American Athletic Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 2 | 264 | 291 | 130 | 555 | 4.27 | 277.5 |
| 2 | South Florida | 1 | 281 | 149 | 66 | 430 | 6.52 | 430.0 |
| 3 | Cincinnati | 1 | 45 | 404 | 63 | 449 | 7.13 | 449.0 |
| 4 | UCF | 1 | 227 | 244 | 81 | 471 | 5.81 | 471.0 |