2016 Conference USA Leaders Total Defense - Games in October Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 762 | 801 | 213 | 1563 | 7.34 | 390.8 |
| 2 | Rice | 4 | 716 | 1512 | 264 | 2228 | 8.44 | 557.0 |
| 3 | UTEP | 4 | 863 | 941 | 266 | 1804 | 6.78 | 451.0 |
| 4 | Charlotte | 4 | 508 | 1063 | 285 | 1571 | 5.51 | 392.8 |
| 5 | Old Dominion | 4 | 725 | 996 | 292 | 1721 | 5.89 | 430.3 |
| 5 | UTSA | 4 | 604 | 1157 | 292 | 1761 | 6.03 | 440.3 |
| 7 | North Texas | 4 | 673 | 789 | 295 | 1462 | 4.96 | 365.5 |
| 7 | Florida Atlantic | 4 | 863 | 1145 | 295 | 2008 | 6.81 | 502.0 |
| 9 | Florida International | 5 | 893 | 1055 | 310 | 1948 | 6.28 | 389.6 |
| 10 | Middle Tennessee | 4 | 693 | 1282 | 341 | 1975 | 5.79 | 493.8 |
| 11 | Western Kentucky | 5 | 556 | 1366 | 361 | 1922 | 5.32 | 384.4 |
| 12 | Louisiana Tech | 5 | 560 | 1384 | 363 | 1944 | 5.36 | 388.8 |
| 13 | Marshall | 5 | 1143 | 1164 | 378 | 2307 | 6.10 | 461.4 |