2025 FBS Independents Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 12/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Notre Dame | 10 | 885 | 2324 | 689 | 3209 | 4.66 | 320.9 |
| 2 | Connecticut | 3 | 404 | 842 | 224 | 1246 | 5.56 | 415.3 |