2025 FBS Independents Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 10/11/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Notre Dame | 5 | 537 | 1257 | 326 | 1794 | 5.50 | 358.8 |
| 2 | Connecticut | 1 | 45 | 416 | 82 | 461 | 5.62 | 461.0 |