2025 American Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 12/13/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Tulane | 10 | 30.0 | 220 | 3.00 |
| 2 | East Carolina | 9 | 25.0 | 151 | 2.78 |
| 3 | USF | 9 | 22.0 | 151 | 2.44 |
| 4 | Florida Atlantic | 10 | 20.0 | 140 | 2.00 |
| 5 | Navy | 11 | 21.0 | 137 | 1.91 |
| 6 | Rice | 10 | 17.0 | 128 | 1.70 |
| 6 | UTSA | 10 | 17.0 | 121 | 1.70 |
| 8 | North Texas | 11 | 17.0 | 107 | 1.55 |
| 9 | Memphis | 10 | 15.0 | 124 | 1.50 |
| 9 | UAB | 10 | 15.0 | 76 | 1.50 |
| 11 | Tulsa | 9 | 13.0 | 88 | 1.44 |
| 12 | Army | 10 | 12.0 | 78 | 1.20 |
| 13 | Temple | 9 | 10.0 | 70 | 1.11 |
| 14 | Charlotte | 9 | 8.0 | 55 | 0.89 |