2025 American Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 11/20/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | East Carolina | 7 | 21.0 | 126 | 3.00 |
| 2 | USF | 7 | 19.0 | 135 | 2.71 |
| 3 | Tulane | 7 | 18.0 | 131 | 2.57 |
| 4 | Rice | 8 | 17.0 | 128 | 2.13 |
| 4 | Florida Atlantic | 8 | 17.0 | 120 | 2.13 |
| 6 | North Texas | 8 | 16.0 | 101 | 2.00 |
| 7 | UTSA | 8 | 14.0 | 107 | 1.75 |
| 8 | Navy | 9 | 15.0 | 101 | 1.67 |
| 9 | Tulsa | 7 | 11.0 | 76 | 1.57 |
| 10 | Memphis | 9 | 14.0 | 111 | 1.56 |
| 11 | UAB | 8 | 11.0 | 55 | 1.38 |
| 12 | Temple | 7 | 9.0 | 64 | 1.29 |
| 13 | Charlotte | 8 | 8.0 | 55 | 1.00 |
| 13 | Army | 7 | 7.0 | 44 | 1.00 |