2025 American Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 11/01/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 2 | 334 | 413 | 116 | 747 | 6.44 | 373.5 |
| 2 | UTSA | 1 | 108 | 291 | 59 | 399 | 6.76 | 399.0 |
| 3 | East Carolina | 1 | 172 | 246 | 60 | 418 | 6.97 | 418.0 |
| 4 | UAB | 2 | 354 | 518 | 133 | 872 | 6.56 | 436.0 |
| 5 | Tulsa | 1 | 191 | 266 | 78 | 457 | 5.86 | 457.0 |
| 6 | Temple | 2 | 535 | 448 | 127 | 983 | 7.74 | 491.5 |
| 7 | Florida Atlantic | 1 | 296 | 196 | 65 | 492 | 7.57 | 492.0 |
| 8 | USF | 2 | 334 | 692 | 147 | 1026 | 6.98 | 513.0 |
| 9 | Tulane | 1 | 241 | 307 | 69 | 548 | 7.94 | 548.0 |