2025 American Conference Leaders Total Defense - Games vs. FBS Teams With Winning Record Only through 09/12/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 1 | 39 | 252 | 71 | 291 | 4.10 | 291.0 |
| 2 | Florida Atlantic | 1 | 112 | 268 | 77 | 380 | 4.94 | 380.0 |
| 3 | Rice | 1 | 204 | 188 | 60 | 392 | 6.53 | 392.0 |
| 4 | East Carolina | 1 | 105 | 318 | 70 | 423 | 6.04 | 423.0 |
| 5 | UTSA | 2 | 276 | 577 | 125 | 853 | 6.82 | 426.5 |
| 6 | UAB | 1 | 295 | 168 | 59 | 463 | 7.85 | 463.0 |
| 7 | Charlotte | 1 | 182 | 404 | 88 | 586 | 6.66 | 586.0 |