2025 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | California | 1 | 7 | 8 | 0 | 15 | 15.0 |
| 1 | Clemson | 1 | 8 | 8 | 0 | 16 | 16.0 |
| 3 | Pittsburgh | 1 | 5 | 7 | 1 | 13 | 13.0 |
| 4 | Virginia | 1 | 2 | 9 | 2 | 13 | 13.0 |
| 4 | Louisville | 2 | 20 | 11 | 2 | 33 | 16.5 |
| 4 | Wake Forest | 1 | 10 | 6 | 2 | 18 | 18.0 |
| 4 | Syracuse | 1 | 7 | 11 | 2 | 20 | 20.0 |
| 4 | North Carolina | 1 | 3 | 16 | 2 | 21 | 21.0 |
| 4 | Duke | 1 | 6 | 14 | 2 | 22 | 22.0 |
| 10 | Florida State | 1 | 3 | 6 | 3 | 12 | 12.0 |
| 10 | Georgia Tech | 1 | 9 | 7 | 3 | 19 | 19.0 |
| 12 | Miami (FL) | 2 | 10 | 19 | 4 | 33 | 16.5 |
| 12 | NC State | 2 | 10 | 28 | 4 | 42 | 21.0 |
| 14 | SMU | 1 | 4 | 10 | 5 | 19 | 19.0 |
| 14 | Virginia Tech | 1 | 11 | 13 | 5 | 29 | 29.0 |
| 16 | Boston College | 2 | 11 | 25 | 6 | 42 | 21.0 |
| 17 | Stanford | 2 | 6 | 34 | 7 | 47 | 23.5 |