2025 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. Ranked Teams Only (AP Poll) through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 9 | 9 | 0 | 18 | 18.0 |
| 1 | California | 1 | 12 | 11 | 0 | 23 | 23.0 |
| 3 | Pittsburgh | 1 | 6 | 16 | 1 | 23 | 23.0 |
| 3 | SMU | 1 | 10 | 12 | 1 | 23 | 23.0 |
| 5 | Louisville | 2 | 13 | 14 | 2 | 29 | 14.5 |
| 5 | North Carolina | 1 | 6 | 8 | 2 | 16 | 16.0 |
| 5 | Miami (FL) | 2 | 16 | 21 | 2 | 39 | 19.5 |
| 5 | Syracuse | 2 | 25 | 23 | 2 | 50 | 25.0 |
| 9 | Duke | 1 | 10 | 8 | 3 | 21 | 21.0 |
| 9 | Virginia | 1 | 5 | 18 | 3 | 26 | 26.0 |
| 11 | Florida State | 3 | 25 | 30 | 4 | 59 | 19.7 |
| 11 | Virginia Tech | 3 | 38 | 27 | 4 | 69 | 23.0 |
| 11 | Wake Forest | 1 | 12 | 11 | 4 | 27 | 27.0 |
| 14 | Stanford | 3 | 33 | 34 | 5 | 72 | 24.0 |
| 15 | Boston College | 2 | 11 | 21 | 6 | 38 | 19.0 |
| 15 | NC State | 3 | 24 | 48 | 6 | 78 | 26.0 |