2025 Atlantic Coast Conference Leaders Total Defense - Games in October Only through 10/24/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 2 | 286 | 286 | 143 | 572 | 4.00 | 286.0 |
| 2 | Pittsburgh | 3 | 273 | 570 | 181 | 843 | 4.66 | 281.0 |
| 3 | Louisville | 2 | 151 | 420 | 122 | 571 | 4.68 | 285.5 |
| 4 | Clemson | 3 | 281 | 634 | 192 | 915 | 4.77 | 305.0 |
| 4 | Syracuse | 2 | 191 | 434 | 131 | 625 | 4.77 | 312.5 |
| 6 | SMU | 3 | 220 | 874 | 224 | 1094 | 4.88 | 364.7 |
| 7 | NC State | 2 | 210 | 463 | 136 | 673 | 4.95 | 336.5 |
| 8 | Miami (FL) | 2 | 251 | 520 | 151 | 771 | 5.11 | 385.5 |
| 9 | Virginia | 2 | 189 | 512 | 137 | 701 | 5.12 | 350.5 |
| 10 | North Carolina | 2 | 169 | 613 | 141 | 782 | 5.55 | 391.0 |
| 11 | Duke | 2 | 212 | 450 | 118 | 662 | 5.61 | 331.0 |
| 12 | Florida State | 3 | 384 | 723 | 197 | 1107 | 5.62 | 369.0 |
| 12 | Virginia Tech | 3 | 398 | 755 | 205 | 1153 | 5.62 | 384.3 |
| 14 | California | 3 | 655 | 551 | 207 | 1206 | 5.83 | 402.0 |
| 15 | Stanford | 2 | 255 | 558 | 132 | 813 | 6.16 | 406.5 |
| 16 | Georgia Tech | 2 | 254 | 554 | 131 | 808 | 6.17 | 404.0 |
| 17 | Boston College | 3 | 491 | 971 | 222 | 1462 | 6.59 | 487.3 |