2025 Big 12 Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 12/06/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Texas Tech | 11 | 33.0 | 253 | 3.00 |
| 2 | BYU | 11 | 26.0 | 196 | 2.36 |
| 2 | Utah | 10 | 26.0 | 194 | 2.60 |
| 4 | Kansas State | 10 | 25.0 | 177 | 2.50 |
| 5 | Arizona State | 10 | 24.0 | 174 | 2.40 |
| 6 | West Virginia | 10 | 22.0 | 166 | 2.20 |
| 6 | UCF | 10 | 22.0 | 125 | 2.20 |
| 8 | TCU | 11 | 20.0 | 119 | 1.82 |
| 9 | Houston | 10 | 19.0 | 110 | 1.90 |
| 9 | Kansas | 10 | 19.0 | 110 | 1.90 |
| 11 | Oklahoma State | 10 | 18.0 | 106 | 1.80 |
| 12 | Cincinnati | 10 | 17.0 | 82 | 1.70 |
| 13 | Arizona | 10 | 14.0 | 102 | 1.40 |
| 14 | Iowa State | 10 | 10.0 | 69 | 1.00 |
| 14 | Baylor | 11 | 10.0 | 55 | 0.91 |
| 16 | Colorado | 10 | 9.0 | 60 | 0.90 |