2021 Big 12 Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 43.0 | 293 | 4.30 |
| 2 | Baylor | 11 | 36.0 | 236 | 3.27 |
| 3 | Iowa State | 11 | 28.0 | 194 | 2.55 |
| 4 | West Virginia | 12 | 25.0 | 170 | 2.08 |
| 4 | Oklahoma | 11 | 25.0 | 167 | 2.27 |
| 6 | Kansas State | 11 | 22.0 | 119 | 2.00 |
| 7 | TCU | 10 | 14.0 | 106 | 1.40 |
| 8 | Kansas | 10 | 13.0 | 93 | 1.30 |
| 8 | Texas | 10 | 13.0 | 85 | 1.30 |
| 10 | Texas Tech | 10 | 12.0 | 80 | 1.20 |