2025 Big 12 Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 09/18/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 1 | 37 | 312 | 8.43 | 5 | 37.00 | 312.00 |
| 2 | Kansas State | 1 | 46 | 130 | 2.83 | 1 | 46.00 | 130.00 |
| 3 | Kansas | 1 | 47 | 261 | 5.55 | 2 | 47.00 | 261.00 |
| 3 | Colorado | 1 | 47 | 320 | 6.81 | 3 | 47.00 | 320.00 |
| 5 | Baylor | 1 | 52 | 307 | 5.90 | 4 | 52.00 | 307.00 |