2025 Big 12 Conference Leaders Opponent First Downs - Games Lost Only through 10/04/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Arizona State | 1 | 5 | 12 | 0 | 17 | 17.0 |
| 2 | Utah | 1 | 7 | 13 | 0 | 20 | 20.0 |
| 3 | Arizona | 1 | 8 | 10 | 1 | 19 | 19.0 |
| 4 | TCU | 1 | 9 | 13 | 3 | 25 | 25.0 |
| 5 | Cincinnati | 1 | 10 | 13 | 0 | 23 | 23.0 |
| 6 | Iowa State | 1 | 12 | 7 | 1 | 20 | 20.0 |
| 7 | Houston | 1 | 16 | 11 | 0 | 27 | 27.0 |
| 8 | UCF | 2 | 17 | 18 | 1 | 36 | 18.0 |
| 9 | Kansas | 2 | 22 | 34 | 1 | 57 | 28.5 |
| 10 | Baylor | 2 | 32 | 13 | 6 | 51 | 25.5 |
| 11 | Oklahoma State | 4 | 40 | 54 | 8 | 102 | 25.5 |
| 12 | Kansas State | 4 | 44 | 36 | 5 | 85 | 21.3 |
| 13 | Colorado | 4 | 47 | 42 | 9 | 98 | 24.5 |
| 14 | West Virginia | 4 | 48 | 42 | 9 | 99 | 24.8 |