2025 Conference USA Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 11/22/2025
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 1 | 1 | 2 | 1 | 0 | 0 | 13 | 13.0 |
| 2 | Jacksonville State | 1 | 2 | 1 | 2 | 0 | 0 | 17 | 17.0 |
| 3 | UTEP | 1 | 3 | 2 | 3 | 0 | 0 | 27 | 27.0 |
| 4 | FIU | 1 | 4 | 2 | 4 | 0 | 0 | 34 | 34.0 |
| 5 | Louisiana Tech | 2 | 6 | 3 | 6 | 0 | 0 | 51 | 25.5 |
| 5 | Middle Tennessee State | 1 | 6 | 0 | 6 | 0 | 0 | 42 | 42.0 |
| 5 | New Mexico State | 1 | 6 | 0 | 6 | 0 | 0 | 42 | 42.0 |
| 8 | Kennesaw State | 2 | 9 | 1 | 9 | 0 | 0 | 66 | 33.0 |
| 8 | Sam Houston State | 2 | 9 | 3 | 9 | 0 | 0 | 72 | 36.0 |
| 8 | Delaware | 2 | 10 | 4 | 9 | 1 | 0 | 83 | 41.5 |
| 11 | Missouri State | 2 | 14 | 1 | 14 | 0 | 0 | 101 | 50.5 |