2025 Conference USA Leaders Opponent First Downs - Games vs. FBS Teams With Winning Record Only through 10/08/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 1 | 8 | 8 | 1 | 17 | 17.0 |
| 2 | UTEP | 4 | 39 | 28 | 8 | 75 | 18.8 |
| 3 | FIU | 3 | 29 | 29 | 8 | 66 | 22.0 |
| 4 | Delaware | 2 | 11 | 31 | 3 | 45 | 22.5 |
| 5 | Louisiana Tech | 3 | 12 | 44 | 13 | 69 | 23.0 |
| 6 | Sam Houston State | 5 | 36 | 72 | 8 | 116 | 23.2 |
| 7 | Western Kentucky | 2 | 18 | 25 | 5 | 48 | 24.0 |
| 7 | Kennesaw State | 2 | 22 | 23 | 3 | 48 | 24.0 |
| 7 | Jacksonville State | 2 | 24 | 19 | 5 | 48 | 24.0 |
| 10 | Liberty | 2 | 24 | 21 | 4 | 49 | 24.5 |
| 11 | Missouri State | 3 | 25 | 41 | 10 | 76 | 25.3 |
| 12 | New Mexico State | 2 | 25 | 20 | 7 | 52 | 26.0 |