2025 Conference USA Leaders Opponent First Downs - Games vs. FBS Teams With Winning Record Only through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 3 | 22 | 27 | 4 | 53 | 17.7 |
| 2 | UTEP | 3 | 33 | 16 | 8 | 57 | 19.0 |
| 3 | FIU | 4 | 35 | 38 | 5 | 78 | 19.5 |
| 4 | Kennesaw State | 4 | 37 | 42 | 8 | 87 | 21.8 |
| 5 | Liberty | 3 | 39 | 24 | 4 | 67 | 22.3 |
| 6 | Western Kentucky | 2 | 15 | 25 | 5 | 45 | 22.5 |
| 7 | Delaware | 3 | 23 | 39 | 7 | 69 | 23.0 |
| 8 | New Mexico State | 4 | 42 | 47 | 9 | 98 | 24.5 |
| 9 | Louisiana Tech | 4 | 24 | 60 | 15 | 99 | 24.8 |
| 10 | Jacksonville State | 1 | 15 | 7 | 3 | 25 | 25.0 |
| 11 | Missouri State | 3 | 25 | 41 | 10 | 76 | 25.3 |
| 11 | Sam Houston State | 6 | 67 | 76 | 9 | 152 | 25.3 |