2022 American Athletic Conference Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 2 | 13 | 35 | 9 | 57 | 28.5 |
| 2 | Tulsa | 1 | 14 | 9 | 3 | 26 | 26.0 |
| 3 | UCF | 3 | 35 | 20 | 8 | 63 | 21.0 |
| 3 | Houston | 2 | 16 | 23 | 3 | 42 | 21.0 |
| 5 | East Carolina | 1 | 4 | 12 | 2 | 18 | 18.0 |
| 6 | South Florida | 2 | 22 | 12 | 0 | 34 | 17.0 |
| 6 | Tulane | 2 | 18 | 14 | 2 | 34 | 17.0 |
| 8 | Cincinnati | 3 | 15 | 32 | 3 | 50 | 16.7 |
| 9 | Memphis | 1 | 6 | 5 | 2 | 13 | 13.0 |
| 10 | Temple | 2 | 10 | 13 | 2 | 25 | 12.5 |