2022 American Athletic Conference Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 2 | 17 | 35 | 6 | 58 | 29.0 |
| 2 | UCF | 2 | 24 | 22 | 5 | 51 | 25.5 |
| 3 | East Carolina | 1 | 9 | 13 | 2 | 24 | 24.0 |
| 4 | Houston | 1 | 9 | 12 | 1 | 22 | 22.0 |
| 5 | Cincinnati | 1 | 12 | 7 | 0 | 19 | 19.0 |
| 6 | Memphis | 2 | 17 | 16 | 3 | 36 | 18.0 |
| 6 | Navy | 1 | 10 | 5 | 3 | 18 | 18.0 |
| 8 | Tulane | 2 | 18 | 14 | 2 | 34 | 17.0 |
| 9 | Tulsa | 1 | 9 | 6 | 1 | 16 | 16.0 |
| 10 | South Florida | 1 | 5 | 9 | 0 | 14 | 14.0 |