2022 American Athletic Conference Leaders Passes Defended - Games in November Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 4 | 2 | 19 | 21 | 5.25 |
| 2 | Tulane | 4 | 3 | 15 | 18 | 4.50 |
| 2 | Temple | 4 | 2 | 16 | 18 | 4.50 |
| 2 | Houston | 4 | 0 | 18 | 18 | 4.50 |
| 5 | Tulsa | 4 | 2 | 14 | 16 | 4.00 |
| 6 | East Carolina | 3 | 3 | 12 | 15 | 5.00 |
| 6 | SMU | 4 | 5 | 10 | 15 | 3.75 |
| 8 | Memphis | 4 | 4 | 8 | 12 | 3.00 |
| 9 | UCF | 4 | 3 | 8 | 11 | 2.75 |
| 10 | Navy | 3 | 2 | 4 | 6 | 2.00 |
| 10 | South Florida | 4 | 0 | 6 | 6 | 1.50 |