2022 American Athletic Conference Leaders Passes Defended - Games Won Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Tulane | 12 | 12 | 38 | 50 | 4.17 |
| 2 | Cincinnati | 9 | 9 | 39 | 48 | 5.33 |
| 3 | UCF | 9 | 5 | 39 | 44 | 4.89 |
| 4 | Houston | 8 | 5 | 34 | 39 | 4.88 |
| 5 | East Carolina | 8 | 8 | 28 | 36 | 4.50 |
| 6 | Memphis | 7 | 13 | 19 | 32 | 4.57 |
| 7 | SMU | 7 | 9 | 20 | 29 | 4.14 |
| 8 | Navy | 4 | 7 | 19 | 26 | 6.50 |
| 9 | Tulsa | 5 | 4 | 16 | 20 | 4.00 |
| 10 | Temple | 3 | 3 | 12 | 15 | 5.00 |
| 11 | USF | 1 | 1 | 1 | 2 | 2.00 |