2022 American Athletic Conference Leaders Interceptions - Games in August/September Only through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sylvonta Oliver | Memphis | SR | DB | 4 | 1 | 71 | 0 | 0.25 |
| 2 | Jayce Rogers | Houston | SR | DB | 5 | 1 | 54 | 1 | 0.20 |
| 3 | Ja'Von Hicks | Cincinnati | SR | S | 4 | 1 | 45 | 1 | 0.25 |
| 4 | Layton Jordan | Temple | JR | OLB | 4 | 1 | 41 | 1 | 0.25 |
| 5 | Jaylon Allen | Memphis | SR | DL | 4 | 1 | 39 | 1 | 0.25 |
| 6 | Xavier Cullens | Memphis | SR | LB | 4 | 1 | 37 | 1 | 0.25 |
| 6 | Art Green | Houston | SR | DB | 4 | 1 | 37 | 0 | 0.25 |
| 6 | Dwayne Boyles | S Florida | SR | LB | 4 | 1 | 37 | 0 | 0.25 |
| 9 | Jireh Wilson | ECU | JR | SAF | 4 | 1 | 34 | 0 | 0.25 |
| 10 | Nelson Ceaser | Houston | SO | DL | 5 | 1 | 32 | 0 | 0.20 |
| 11 | Bryon Threats | Cincinnati | SO | S | 4 | 1 | 28 | 0 | 0.25 |
| 12 | Nick Roberts | SMU | SR | S | 4 | 1 | 27 | 0 | 0.25 |
| 13 | Gervarrius Owens | Houston | SR | DB | 4 | 1 | 24 | 0 | 0.25 |
| 14 | Jarius Monroe | Tulane | JR | DB | 5 | 1 | 22 | 0 | 0.20 |
| 15 | Alex Odom | Temple | SO | SAF | 4 | 1 | 21 | 0 | 0.25 |
| 16 | Thabo Mwaniki | Houston | SR | DB | 5 | 1 | 19 | 0 | 0.20 |
| 17 | Dorian Williams | Tulane | SR | LB | 5 | 1 | 13 | 0 | 0.20 |
| 18 | Mekhi LaPointe | S Florida | SR | DB | 4 | 1 | 12 | 0 | 0.25 |
| 19 | Chance Bates | ECU | SR | ILB | 4 | 1 | 11 | 0 | 0.25 |
| 20 | Taj Ward | Cincinnati | SR | CB | 4 | 1 | 4 | 0 | 0.25 |
| 21 | Stephon Wright | SMU | JR | DT | 2 | 1 | 1 | 0 | 0.50 |
| 21 | Shanon Reid | SMU | SR | LB | 4 | 1 | 1 | 0 | 0.25 |