2022 Atlantic Coast Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 4 | 577 | 748 | 286 | 1325 | 4.63 | 331.3 |
| 2 | Syracuse | 6 | 929 | 1159 | 421 | 2088 | 4.96 | 348.0 |
| 3 | Florida State | 6 | 1047 | 947 | 396 | 1994 | 5.04 | 332.3 |
| 4 | Miami (Florida) | 5 | 651 | 1007 | 328 | 1658 | 5.05 | 331.6 |
| 5 | Clemson | 7 | 914 | 1584 | 491 | 2498 | 5.09 | 356.9 |
| 6 | North Carolina State | 6 | 826 | 1338 | 423 | 2164 | 5.12 | 360.7 |
| 7 | Pittsburgh | 6 | 484 | 1464 | 364 | 1948 | 5.35 | 324.7 |
| 8 | Wake Forest | 6 | 781 | 1477 | 409 | 2258 | 5.52 | 376.3 |
| 9 | Duke | 7 | 831 | 1988 | 506 | 2819 | 5.57 | 402.7 |
| 10 | Louisville | 7 | 1027 | 1451 | 441 | 2478 | 5.62 | 354.0 |
| 11 | Virginia Tech | 6 | 910 | 1477 | 424 | 2387 | 5.63 | 397.8 |
| 12 | Boston College | 6 | 1027 | 1267 | 400 | 2294 | 5.74 | 382.3 |
| 13 | Georgia Tech | 6 | 1201 | 1261 | 421 | 2462 | 5.85 | 410.3 |
| 14 | North Carolina | 8 | 1495 | 2362 | 575 | 3857 | 6.71 | 482.1 |