2022 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 1 | 120 | 190 | 65 | 310 | 4.77 | 310.0 |
| 2 | Syracuse | 4 | 930 | 639 | 303 | 1569 | 5.18 | 392.3 |
| 3 | Florida State | 2 | 306 | 412 | 132 | 718 | 5.44 | 359.0 |
| 4 | Virginia | 1 | 189 | 208 | 72 | 397 | 5.51 | 397.0 |
| 5 | Clemson | 4 | 648 | 950 | 276 | 1598 | 5.79 | 399.5 |
| 6 | North Carolina State | 2 | 351 | 390 | 126 | 741 | 5.88 | 370.5 |
| 7 | Louisville | 3 | 605 | 615 | 203 | 1220 | 6.01 | 406.7 |
| 8 | Georgia Tech | 4 | 735 | 1103 | 297 | 1838 | 6.19 | 459.5 |
| 9 | Pittsburgh | 2 | 219 | 650 | 138 | 869 | 6.30 | 434.5 |
| 10 | Wake Forest | 2 | 300 | 652 | 149 | 952 | 6.39 | 476.0 |
| 11 | North Carolina | 4 | 695 | 1047 | 264 | 1742 | 6.60 | 435.5 |
| 12 | Miami (Florida) | 3 | 678 | 727 | 212 | 1405 | 6.63 | 468.3 |
| 13 | Boston College | 3 | 605 | 726 | 193 | 1331 | 6.90 | 443.7 |
| 14 | Virginia Tech | 1 | 326 | 170 | 71 | 496 | 6.99 | 496.0 |