2022 Atlantic Coast Conference Leaders Total Defense - Games in November Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 2 | 351 | 501 | 149 | 852 | 5.72 | 426.0 |
| 2 | Virginia Tech | 3 | 490 | 732 | 212 | 1222 | 5.76 | 407.3 |
| 3 | Pittsburgh | 4 | 186 | 841 | 243 | 1027 | 4.23 | 256.8 |
| 3 | Clemson | 4 | 498 | 763 | 243 | 1261 | 5.19 | 315.3 |
| 5 | Florida State | 4 | 615 | 484 | 244 | 1099 | 4.50 | 274.8 |
| 6 | Georgia Tech | 4 | 782 | 647 | 253 | 1429 | 5.65 | 357.3 |
| 7 | Louisville | 4 | 624 | 645 | 258 | 1269 | 4.92 | 317.3 |
| 8 | Boston College | 4 | 871 | 734 | 262 | 1605 | 6.13 | 401.3 |
| 9 | Duke | 4 | 405 | 1044 | 266 | 1449 | 5.45 | 362.3 |
| 10 | Miami (Florida) | 4 | 807 | 961 | 282 | 1768 | 6.27 | 442.0 |
| 11 | North Carolina | 4 | 601 | 1010 | 284 | 1611 | 5.67 | 402.8 |
| 12 | Wake Forest | 4 | 487 | 1406 | 288 | 1893 | 6.57 | 473.3 |
| 13 | North Carolina State | 4 | 326 | 1113 | 297 | 1439 | 4.85 | 359.8 |
| 14 | Syracuse | 4 | 692 | 949 | 312 | 1641 | 5.26 | 410.3 |