2022 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 1 | 188 | 166 | 67 | 354 | 5.28 | 354.0 |
| 2 | Middle Tennessee | 1 | 60 | 307 | 89 | 367 | 4.12 | 367.0 |
| 3 | UTSA | 1 | 298 | 161 | 59 | 459 | 7.78 | 459.0 |
| 4 | UTEP | 1 | 259 | 233 | 61 | 492 | 8.07 | 492.0 |
| 5 | Rice | 1 | 208 | 330 | 58 | 538 | 9.28 | 538.0 |
| 6 | UAB | 1 | 269 | 299 | 72 | 568 | 7.89 | 568.0 |
| 7 | Western Kentucky | 2 | 372 | 486 | 152 | 858 | 5.64 | 429.0 |
| 8 | Louisiana Tech | 2 | 603 | 476 | 154 | 1079 | 7.01 | 539.5 |
| 9 | Charlotte | 2 | 488 | 669 | 128 | 1157 | 9.04 | 578.5 |