2021 National Leaders Passes Defended - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Trenton Thompson | SDSU | SR | S | 4 | 2 | 8 | 10 | 2.50 |
| 2 | Roger Cray | ODU | SR | CB | 3 | 1 | 6 | 7 | 2.33 |
| 2 | Mario Goodrich | Clemson | SR | CB | 3 | 0 | 7 | 7 | 2.33 |
| 4 | Cortez Davis | Hawai'i | SR | DB | 4 | 1 | 7 | 8 | 2.00 |
| 5 | Coby Bryant | Cincinnati | SR | CB | 5 | 3 | 6 | 9 | 1.80 |
| 6 | Zyon Gilbert | FAU | SR | CB | 4 | 1 | 6 | 7 | 1.75 |
| 6 | Kei'Trel Clark | Louisville | SO | DB | 4 | 0 | 7 | 7 | 1.75 |
| 6 | Roger McCreary | Auburn | SR | CB | 4 | 0 | 7 | 7 | 1.75 |
| 9 | Erick Hallett II | Pittsburgh | JR | DB | 4 | 1 | 5 | 6 | 1.50 |
| 9 | Tyreek Chappell | Texas A&M | FR | DB | 4 | 1 | 5 | 6 | 1.50 |
| 9 | Malik Fleming | ECU | SO | CB | 4 | 1 | 5 | 6 | 1.50 |
| 9 | Cam Taylor-Britt | Nebraska | JR | CB | 4 | 1 | 5 | 6 | 1.50 |
| 9 | Reed Blankenship | MTSU | SR | S | 4 | 0 | 6 | 6 | 1.50 |
| 9 | Greedy Vance | Louisville | FR | DB | 4 | 0 | 6 | 6 | 1.50 |
| 9 | Clark Phillips III | Utah | FR | CB | 4 | 0 | 6 | 6 | 1.50 |
| 9 | Tarheeb Still | Maryland | SO | DB | 4 | 0 | 6 | 6 | 1.50 |
| 17 | Darrell Luter Jr. | USA | JR | CB | 5 | 3 | 4 | 7 | 1.40 |
| 18 | Cam Smith | S Carolina | SO | DB | 3 | 0 | 4 | 4 | 1.33 |
| 19 | Khoury Bethley | Hawai'i | SR | DB | 4 | 3 | 2 | 5 | 1.25 |
| 19 | Evan Williams | Fresno St | JR | DB | 4 | 3 | 2 | 5 | 1.25 |
| 19 | Jalen Graham | Purdue | JR | LB | 4 | 2 | 3 | 5 | 1.25 |
| 19 | Daxton Hill | Michigan | JR | DB | 4 | 2 | 3 | 5 | 1.25 |
| 19 | Eric Garror | La-Lafytte | JR | CB | 4 | 2 | 3 | 5 | 1.25 |
| 19 | DJ James | Oregon | SO | CB | 4 | 2 | 3 | 5 | 1.25 |
| 19 | R'Tarriun Johnson | ODU | JR | S | 4 | 2 | 3 | 5 | 1.25 |
| 19 | Damarion Williams | Houston | SR | CB | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Travon Fuller | Tulsa | SR | CB | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Tre Bugg III | Air Force | SR | DB | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Trey Dean III | Florida | SR | S | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Qwynnterrio Cole | Louisville | SR | DB | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Ja'Quan McMillian | ECU | SO | CB | 4 | 1 | 4 | 5 | 1.25 |
| 19 | Tyon Davis | Tulsa | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Ronald Williams | Mich St | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Garrett Williams | Syracuse | FR | DB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Robert Longerbeam | Rutgers | FR | DB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Praise Amaewhule | UTEP | SO | DE | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Jaylon Monroe | Tulane | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Dorian Jackson | W Mich | JR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Samuel Womack | Toledo | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 19 | Darrius Bratton | Virginia | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 41 | Nehemiah Shelton | SJSU | SR | CB | 5 | 1 | 5 | 6 | 1.20 |
| 41 | Josh Newton | La-Monroe | SO | CB | 5 | 1 | 5 | 6 | 1.20 |
| 41 | Davonte Brown | UCF | SO | DB | 5 | 1 | 5 | 6 | 1.20 |
| 41 | Kaleb Hayes | BYU | JR | DB | 5 | 0 | 6 | 6 | 1.20 |
| 45 | Daiyan Henley | Nevada | SR | LB | 5 | 4 | 1 | 5 | 1.00 |
| 45 | Malik Moore | BYU | JR | DB | 5 | 2 | 3 | 5 | 1.00 |
| 45 | Jordan Anderson | BGSU | JR | S | 5 | 2 | 3 | 5 | 1.00 |
| 45 | Will Ignont | Western Ky | JR | LB | 5 | 1 | 4 | 5 | 1.00 |
| 45 | Devin Taylor | BGSU | SR | CB | 5 | 1 | 4 | 5 | 1.00 |
| 45 | Duron Lowe | Liberty | SR | CB | 5 | 1 | 4 | 5 | 1.00 |
| 45 | Cam Allen | Purdue | JR | S | 4 | 3 | 1 | 4 | 1.00 |
| 45 | Steven Jones Jr. | App St | SR | DB | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Gregory Grate | MTSU | JR | S | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Tre Wortham | UConn | JR | DB | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Jordan Battle | Alabama | JR | DB | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Jason Taylor II | Okla St | JR | S | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Nate Rutchena | California | FR | ILB | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Elijah Hicks | California | SR | S | 4 | 2 | 2 | 4 | 1.00 |
| 45 | Alex Hogan | Houston | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Marcus Jones | Houston | SR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Reddy Steward | Troy | SO | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Antavious Lane | Georgia St | SO | S | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Trey Cobb | App St | SR | ILB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Nazeeh Johnson | Marshall | SR | S | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Jack Jones | Ariz St | SR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Shyheim Battle | NC State | FR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Aydan White | NC State | FR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Russ Yeast | Kansas St | SR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Lance Boykin | Coast Car | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | J.T. Wahee | Ball State | SR | S | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Korel Smith | FAU | SR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Romain Mungin | FAU | SO | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Hugh Nelson II | Hawai'i | JR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | LJ Early | Fresno St | SR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Miles McCord | Rice | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Brandon Joseph | N'western | SO | SAF | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Bryce Watts | U Mass | JR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Dwight McGlothern | LSU | SO | CB | 4 | 1 | 3 | 4 | 1.00 |
| 45 | Kyler Gordon | Washington | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Jaylin Williams | Indiana | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Tariq Castro-Fields | Penn State | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Bryquice Brown | Georgia St | SO | CB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Micah Abraham | Marshall | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Brandon Hill | Pittsburgh | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Donte Kent | CMU | FR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Cedric Woods | La Tech | FR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | D'Jordan Strong | Coast Car | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Jalen Alexander | Duke | JR | S | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Kyu Blu Kelly | Stanford | JR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Teja Young | FAU | SO | S | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Anthony Wilson | Ga South | SO | S | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Joe Joe Headen | ODU | SR | S | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Alontae Taylor | Tennessee | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Tayler Hawkins | SDSU | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 45 | Deontai Williams | Nebraska | SR | S | 3 | 2 | 1 | 3 | 1.00 |
| 45 | Joey Blount | Virginia | SR | FS | 3 | 2 | 1 | 3 | 1.00 |
| 45 | Terry Roberts | Iowa | JR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 45 | Brendan Radley-Hiles | Washington | JR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 45 | Josh Wallace | U Mass | SO | CB | 3 | 0 | 3 | 3 | 1.00 |
| 100 | Jakob Robinson | BYU | FR | DB | 5 | 1 | 3 | 4 | 0.80 |
Note: To qualify, player must have played in 75% of his team's games.