2021 National Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cole Godbout | Wyoming | JR | NT | 1 | 0 | 3 | 3 | 3.00 |
| 1 | Micah Abraham | Marshall | SO | DB | 1 | 0 | 3 | 3 | 3.00 |
| 3 | Faion Hicks | Wisconsin | SR | CB | 3 | 0 | 8 | 8 | 2.67 |
| 4 | Roger McCreary | Auburn | SR | CB | 4 | 0 | 10 | 10 | 2.50 |
| 5 | Jermari Harris | Iowa | SO | DB | 2 | 2 | 2 | 4 | 2.00 |
| 5 | Evan Williams | Fresno St | JR | DB | 2 | 1 | 3 | 4 | 2.00 |
| 5 | Tayler Hawkins | SDSU | SR | CB | 2 | 1 | 3 | 4 | 2.00 |
| 5 | Bobby Brown, II | SJSU | SR | DB | 2 | 0 | 4 | 4 | 2.00 |
| 5 | Chris McDonald | Toledo | SO | CB | 1 | 1 | 1 | 2 | 2.00 |
| 5 | Charles Amankwaa | Akron | JR | DB | 1 | 1 | 1 | 2 | 2.00 |
| 5 | Quinyon Mitchell | Toledo | FR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Jamal Hines | Toledo | JR | OLB | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Cam Goode | UCF | JR | DL | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Isaiah Essissima | Nevada | JR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Quindell Johnson | Memphis | JR | DB | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Azizi Hearn | Wyoming | SR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 17 | Erick Hallett II | Pittsburgh | JR | DB | 3 | 2 | 3 | 5 | 1.67 |
| 18 | Warren Saba | ECU | SR | SAF | 2 | 2 | 1 | 3 | 1.50 |
| 18 | Corvan Taylor | Air Force | SR | SS | 2 | 1 | 2 | 3 | 1.50 |
| 18 | Trenton Thompson | SDSU | SR | S | 2 | 0 | 3 | 3 | 1.50 |
| 18 | Shaun Jolly | App St | SR | DB | 2 | 0 | 3 | 3 | 1.50 |
| 22 | Cam Taylor-Britt | Nebraska | JR | CB | 5 | 0 | 7 | 7 | 1.40 |
| 23 | Woodi Washington | Oklahoma | SO | CB | 3 | 2 | 2 | 4 | 1.33 |
| 23 | Cam Smith | S Carolina | SO | DB | 3 | 1 | 3 | 4 | 1.33 |
| 23 | Bryan Cook | Cincinnati | SR | S | 3 | 1 | 3 | 4 | 1.33 |
| 23 | Chris Steele | USC | JR | CB | 3 | 1 | 3 | 4 | 1.33 |
| 23 | Brandon Hill | Pittsburgh | SO | DB | 3 | 1 | 3 | 4 | 1.33 |
| 23 | A.J. Woods | Pittsburgh | JR | DB | 3 | 1 | 3 | 4 | 1.33 |
| 23 | Allan George | Vanderbilt | SR | CB | 3 | 0 | 4 | 4 | 1.33 |
| 23 | Syrus Dumas | NMSU | SO | DB | 3 | 0 | 4 | 4 | 1.33 |
| 31 | Verone McKinley III | Oregon | SO | S | 4 | 2 | 3 | 5 | 1.25 |
| 31 | Denzel Burke | Ohio State | FR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 31 | Jarrick Bernard-Converse | Okla St | SR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 34 | Clark Phillips III | Utah | FR | CB | 5 | 1 | 5 | 6 | 1.20 |
| 34 | Jaylin Williams | Indiana | SR | DB | 5 | 0 | 6 | 6 | 1.20 |
| 36 | JT Woods | Baylor | SR | S | 5 | 4 | 1 | 5 | 1.00 |
| 36 | Christopher Smith | Georgia | SR | DB | 5 | 2 | 3 | 5 | 1.00 |
| 36 | Theo Jackson | Tennessee | SR | DB | 5 | 0 | 5 | 5 | 1.00 |
| 36 | Cam'Ron Kelly | N Carolina | JR | DB | 4 | 2 | 2 | 4 | 1.00 |
| 36 | Andrew Booth Jr. | Clemson | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 36 | Josh Sanguinetti | Indiana | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 36 | JoJo Domann | Nebraska | SR | OLB | 4 | 1 | 3 | 4 | 1.00 |
| 36 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 1 | 3 | 4 | 1.00 |
| 36 | Darian Chestnut | Syracuse | FR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 36 | DaMarcus Fields | Texas Tech | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Treydan Stukes | Arizona | FR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Jaylon Monroe | Tulane | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Cameron Brown | Ohio State | JR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Darrius Bratton | Virginia | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Tarheeb Still | Maryland | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Zakoby McClain | Auburn | SR | LB | 4 | 0 | 4 | 4 | 1.00 |
| 36 | Jaylan Foster | S Carolina | SR | DB | 3 | 3 | 0 | 3 | 1.00 |
| 36 | Payton Wilgar | BYU | SO | LB | 3 | 1 | 2 | 3 | 1.00 |
| 36 | Jakob Robinson | BYU | FR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 36 | Tre'Vez Johnson | Florida | SO | S | 3 | 1 | 2 | 3 | 1.00 |
| 36 | Miles Battle | Miss | JR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 36 | Gabe Reid | Stanford | SR | OLB | 3 | 1 | 2 | 3 | 1.00 |
| 36 | Anthony Wilson | Ga South | SO | S | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Tre Avery | Rutgers | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Antonio Johnson | Texas A&M | SO | DB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Montaric Brown | Arkansas | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Coby Bryant | Cincinnati | SR | CB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Deane Leonard | Miss | SR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | CJ Burton | BC | FR | DB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Kyu Blu Kelly | Stanford | JR | CB | 3 | 0 | 3 | 3 | 1.00 |
| 36 | Sean Fresch | Rice | FR | CB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Levelle Bailey | Fresno St | JR | LB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Patrick McMorris | SDSU | JR | S | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Jack Jones | Ariz St | SR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Kejuan Markham | Ariz St | JR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Shyheim Battle | NC State | FR | CB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Tyler Baker-Williams | NC State | JR | NIC | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Cam'Ron Carter | CSU | SR | LB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Robert Floyd | CSU | FR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Steven Jones Jr. | App St | SR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Ricky Johnson | UNLV | SO | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Cameron Oliver | UNLV | FR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Jay Shaw | UCLA | SR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Mark Perry | Colorado | SO | S | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Stan Cross | UConn | SO | DB | 2 | 1 | 1 | 2 | 1.00 |
| 36 | Justin Walley | Minnesota | FR | DB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Keilos Swinney | La-Monroe | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Miles McCord | Rice | JR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Naeem Smith | Rice | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Justin Houston | Fresno St | SO | H | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Ralph Holley | W Mich | SR | DL | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Dy'jonn Turner | UAB | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | CJ Baskerville | SDSU | FR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Devan Boykin | NC State | FR | NIC | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Davin Vann | NC State | FR | DT | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Nick Heninger | Utah State | SR | DE | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Hunter Reynolds | Utah State | JR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | M.J. Griffin | Temple | FR | SAF | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Cameron Ruiz | Temple | JR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Armani Chatman | Va Tech | SO | DB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Chamarri Conner | Va Tech | JR | DB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Bryce Jackson | UNLV | SR | DB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Lummie Young IV | Duke | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Josh Blackwell | Duke | SR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 36 | Chace Cromartie | SMU | JR | S | 2 | 0 | 2 | 2 | 1.00 |
Note: To qualify, player must have played in 75% of his team's games.