2021 American Athletic Conference Leaders Fumbles Lost - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Fumbles | Fumbles Lost | Fumble Lost % | |
|---|---|---|---|---|---|
| 1 | Houston | 11 | 8 | 2 | 25.00 |
| 2 | SMU | 10 | 10 | 6 | 60.00 |
| 3 | Temple | 9 | 11 | 8 | 72.73 |
| 4 | Cincinnati | 11 | 12 | 8 | 66.67 |
| 5 | UCF | 10 | 13 | 6 | 46.15 |
| 5 | Memphis | 10 | 13 | 8 | 61.54 |
| 7 | Tulsa | 10 | 15 | 7 | 46.67 |
| 7 | USF | 9 | 15 | 8 | 53.33 |
| 7 | Tulane | 9 | 15 | 8 | 53.33 |
| 10 | East Carolina | 10 | 18 | 11 | 61.11 |
| 11 | Navy | 12 | 20 | 5 | 25.00 |