2021 American Athletic Conference Leaders Total Offense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 466 | 1368 | 294 | 1834 | 6.24 | 458.5 |
| 2 | East Carolina | 4 | 784 | 1019 | 307 | 1803 | 5.87 | 450.8 |
| 3 | Memphis | 4 | 585 | 1198 | 302 | 1783 | 5.90 | 445.8 |
| 4 | Cincinnati | 5 | 927 | 1103 | 306 | 2030 | 6.63 | 406.0 |
| 5 | Houston | 4 | 455 | 1130 | 275 | 1585 | 5.76 | 396.3 |
| 6 | Tulsa | 4 | 664 | 861 | 276 | 1525 | 5.53 | 381.3 |
| 7 | South Florida | 4 | 846 | 675 | 270 | 1521 | 5.63 | 380.3 |
| 8 | Tulane | 4 | 599 | 821 | 265 | 1420 | 5.36 | 355.0 |
| 9 | UCF | 5 | 882 | 822 | 313 | 1704 | 5.44 | 340.8 |
| 10 | Temple | 4 | 419 | 822 | 248 | 1241 | 5.00 | 310.3 |
| 11 | Navy | 5 | 1217 | 281 | 359 | 1498 | 4.17 | 299.6 |