2021 American Athletic Conference Leaders Total Offense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 4 | 824 | 1201 | 281 | 2025 | 7.21 | 506.3 |
| 2 | Cincinnati | 4 | 711 | 1174 | 268 | 1885 | 7.03 | 471.3 |
| 3 | East Carolina | 4 | 643 | 1154 | 314 | 1797 | 5.72 | 449.3 |
| 4 | Tulsa | 4 | 837 | 889 | 301 | 1726 | 5.73 | 431.5 |
| 5 | SMU | 4 | 542 | 1016 | 291 | 1558 | 5.35 | 389.5 |
| 6 | Tulane | 4 | 755 | 783 | 264 | 1538 | 5.83 | 384.5 |
| 7 | Memphis | 4 | 310 | 1217 | 294 | 1527 | 5.19 | 381.8 |
| 8 | UCF | 4 | 625 | 807 | 243 | 1432 | 5.89 | 358.0 |
| 9 | South Florida | 4 | 424 | 930 | 291 | 1354 | 4.65 | 338.5 |
| 10 | Navy | 3 | 729 | 127 | 178 | 856 | 4.81 | 285.3 |
| 11 | Temple | 4 | 413 | 448 | 234 | 861 | 3.68 | 215.3 |