2021 American Athletic Conference Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Tulane University | 4 | 32.0 | 139 | 8.00 |
| 2 | University of Houston | 4 | 27.0 | 108 | 6.75 |
| 3 | Temple University | 4 | 30.0 | 103 | 7.50 |
| 3 | East Carolina University | 4 | 29.0 | 103 | 7.25 |
| 5 | The University of Tulsa | 4 | 31.0 | 101 | 7.75 |
| 6 | University of Memphis | 4 | 22.0 | 81 | 5.50 |
| 7 | Southern Methodist University | 4 | 16.0 | 66 | 4.00 |
| 8 | University of Central Florida | 3 | 16.0 | 50 | 5.33 |
| 9 | U.S. Naval Academy | 3 | 14.0 | 48 | 4.67 |
| 10 | University of Cincinnati | 3 | 19.0 | 42 | 6.33 |
| 11 | University of South Florida | 4 | 11.0 | 33 | 2.75 |