2021 American Athletic Conference Leaders Tackles For Loss - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Tulane University | 4 | 24.0 | 113 | 6.00 |
| 2 | University of Cincinnati | 3 | 25.0 | 103 | 8.33 |
| 3 | East Carolina University | 2 | 18.0 | 87 | 9.00 |
| 4 | The University of Tulsa | 4 | 19.0 | 62 | 4.75 |
| 5 | Temple University | 2 | 15.0 | 58 | 7.50 |
| 6 | U.S. Naval Academy | 3 | 18.0 | 50 | 6.00 |
| 7 | University of South Florida | 4 | 12.0 | 38 | 3.00 |
| 8 | Southern Methodist University | 2 | 9.0 | 21 | 4.50 |
| 9 | University of Memphis | 1 | 4.0 | 18 | 4.00 |
| 10 | University of Houston | 1 | 3.0 | 15 | 3.00 |
| 11 | University of Central Florida | 1 | 2.0 | 13 | 2.00 |