2021 American Athletic Conference Leaders Tackles For Loss - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | University of Central Florida | 8 | 57.0 | 260 | 7.13 |
| 2 | University of Houston | 8 | 57.0 | 242 | 7.13 |
| 3 | Temple University | 6 | 38.0 | 148 | 6.33 |
| 4 | Southern Methodist University | 7 | 36.0 | 145 | 5.14 |
| 5 | University of Cincinnati | 5 | 38.0 | 140 | 7.60 |
| 6 | The University of Tulsa | 7 | 39.0 | 122 | 5.57 |
| 7 | University of Memphis | 4 | 20.0 | 93 | 5.00 |
| 8 | Tulane University | 2 | 17.0 | 68 | 8.50 |
| 9 | East Carolina University | 5 | 19.0 | 59 | 3.80 |
| 10 | U.S. Naval Academy | 2 | 9.0 | 49 | 4.50 |
| 11 | University of South Florida | 3 | 11.0 | 46 | 3.67 |