2021 American Athletic Conference Leaders Passes Defended - Games Lost Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 3 | 13 | 16 | 4.00 |
| 2 | Memphis | 6 | 5 | 18 | 23 | 3.83 |
| 3 | Tulane | 10 | 7 | 28 | 35 | 3.50 |
| 4 | UCF | 4 | 2 | 11 | 13 | 3.25 |
| 5 | East Carolina | 5 | 5 | 10 | 15 | 3.00 |
| 5 | Cincinnati | 1 | 1 | 2 | 3 | 3.00 |
| 7 | Temple | 9 | 4 | 22 | 26 | 2.89 |
| 8 | Navy | 8 | 5 | 18 | 23 | 2.88 |
| 9 | USF | 10 | 8 | 20 | 28 | 2.80 |
| 10 | Tulsa | 6 | 4 | 12 | 16 | 2.67 |
| 11 | Houston | 2 | 0 | 4 | 4 | 2.00 |