2021 American Athletic Conference Leaders Passes Defended - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 7 | 35 | 42 | 5.25 |
| 2 | Memphis | 7 | 6 | 28 | 34 | 4.86 |
| 3 | SMU | 4 | 2 | 17 | 19 | 4.75 |
| 4 | Temple | 5 | 3 | 20 | 23 | 4.60 |
| 5 | Houston | 5 | 4 | 14 | 18 | 3.60 |
| 6 | East Carolina | 6 | 7 | 14 | 21 | 3.50 |
| 6 | UCF | 4 | 3 | 11 | 14 | 3.50 |
| 8 | Tulane | 9 | 7 | 22 | 29 | 3.22 |
| 9 | Navy | 10 | 6 | 25 | 31 | 3.10 |
| 10 | Tulsa | 5 | 6 | 9 | 15 | 3.00 |
| 11 | USF | 8 | 5 | 17 | 22 | 2.75 |